PO
,
Adult
Partial seizure, Monotherapy:
1) initiation of monotherapy,
300 mg twice a day, then increase by 300 mg/day every third
day to 1200 mg/day OR 2400mg/day in patients converted
from other antiepileptic drug therapy to oxcarbazepine
monotherapy.
2) conversion to monotherapy,
initial, 300 mg twice a day; may increase by up to 600
mg/day at weekly intervals to 2400 mg/day reached in about
2-4 weeks while simultaneously reduce the dose of
concomitant antiepileptic drugs over 3-6 weeks.
Partial seizure; Adjunct:
initial, 300 mg twice a day; may increase by up to 600 mg/day
at weekly intervals to 1200mg/day.
Pediatric
With adjunctive therapy:
1) 2 to less than 4
years old ─
up to twice the oxcarbazepine dose per body
weight
compared to adults.
2) 4 to less than or equal to 12 years old ─
a 50% higher oxcarbazepine dose per body weight
compared to adults.
Partial seizure, Monotherapy:
1) 4 to 16 year old ─
initiation of monotherapy, 8-10
mg/kg/day in 2 divided doses; may increase dose by 5 mg/kg/day every 3 days
to the recommended maintenance dose.
conversion to monotherapy, initial, 8-10
mg/kg/day in 2
divided doses; may increase doses by up to 10 mg/kg/day at
weekly intervals to the recommended maintenance dose;
simultaneously reduce the dose of concomitant antiepileptic
drugs over 3-6 weeks.
maintenance, 600 to 900 mg/day for
20 kg
children; 900 to
1200 mg/day for 25 to
30 kg
;
900 to 1500 mg/day for 35 to
40 kg
children; 1200 to 1500 mg/day for
45 kg
children;
1200 to 1800 mg/day for 50 to
55 kg
children; 1200 to 2100
mg/day for 60 to
70 kg
children.
Partial seizure; Adjunct:
1) 4 to 16 year old ─
initial,
8-10 mg/kg/day in 2 divided doses; Max. 600 mg/day.
maintenance, target maintenance dose of oxcarbazepine
should be achieved over 2 weeks, and is dependent upon
patient weight: (20 to
29 kg
,
900 mg/day); (29.1 to
39 kg
,
1200 mg/day); and (greater than
39 kg
, 1800 mg/day).
2) 2 to less than 4 years old ─
initial, 8-10 mg/kg/day in 2
divided doses; Max. 600 mg/day;
patients under
20 kg
,
consider initial dose of 16-20 mg/kg/day
in 2 divided doses.
maintenance, should be titrated over 2 to 4 weeks; Max. 60
mg/kg/day in 2 divided doses. |
