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LEVOFLOXACIN 750MG(疾管局申請)　　　　　　　　

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,Levofloxacin 750mg

現行藥物外觀

中文名:佐淨菌

廠牌:中化/疾病管制局

 

 
Product name
CRAVIT TAB.750MG(疾管局申請)
Dosage form
 
Indications
  • Bacterial conjunctivitis
  • Bacterial prostatitis, chronic
  • Bacterial sinusitis, acute
  • Bronchitis, chronic, acute bacterial exacerbation
  • Community acquired pneumonia
  • Corneal ulcer
  • Infection of skin AND/OR subcutaneous tissue
  • Inhalational anthrax, Post-exposure; Prophylaxis
  • Nosocomial pneumonia
  • Pyelonephritis, acute (Mild to Moderate)
  • Urinary tract infectious disease
Administration & Dosage
 
Adult Dosing
 
  • Bacterial conjunctivitis: (0.5% ophthalmic solution) day 1-2, 1-2 drops every 2 hr while awake (MAX 8 times/day); day 3-7, 1-2 drops every 4 hr while awake (MAX 4 times/day)
  • Bacterial prostatitis, chronic: 500 mg IV or ORALLY every 24 hr for 28 days
  • Bacterial sinusitis, acute: 750 mg IV or ORALLY every 24 hr for 5 days or 500 mg IV or ORALLY every 24 hr for 10-14 days
  • Bronchitis, chronic, acute bacterial exacerbation: 500 mg IV or ORALLY every 24 hr for 7 days
  • Chlamydial infection: 500 mg ORALLY once a day for 7 days
  • Community acquired pneumonia: 500 mg IV or ORALLY every 24 hr for 7-14 days or 750 mg IV or ORALLY every 24 hr for 5 days
  • Corneal ulcer: (1.5% ophthalmic solution) day 1-3, 1-2 drops every 30 min to 2 hr while awake and 4 hr and 6 hr after retiring; day 4 through treatment end, 1-2 drops every 1 to 4 hr while awake
  • Epididymitis: (caused by enteric organisms or with negative gonococcal culture or nucleic acid amplification test) 500 mg ORALLY once daily for 10 days
  • Infection of skin AND/OR subcutaneous tissue: (uncomplicated) 500 mg IV or ORALLY every 24 hr for 7-10 days
  • Infection of skin AND/OR subcutaneous tissue: (complicated) 750 mg IV or ORALLY every 24 hr for 7-14 days
  • Inhalational anthrax, Post-exposure; Prophylaxis: 500 mg IV or ORALLY every 24 hr for 60 days
  • Nongonococcal urethritis: 500 mg ORALLY once daily for 7 days
  • Nosocomial pneumonia: 750 mg IV or ORALLY every 24 hr for 7-14 days
  • Pyelonephritis, acute (Mild to Moderate): 250 mg IV or ORALLY every 24 hr for 10 days
  • Traveler's diarrhea: 500 mg ORALLY once daily for 1-3 days
  • Urinary tract infectious disease: (uncomplicated) 250 mg IV or ORALLY every 24 hr for 3 days
  • Urinary tract infectious disease: (complicated) 250 mg IV or ORALLY every 24 hr for 10 days
 
Pediatric Dosing
 
  • safety and efficacy in children under 18 years of age have not been established (oral/IV)
  • Bacterial conjunctivitis: (0.5% ophthalmic solution) ages 1 year and older; day 1-2, 1-2 drops every 2 hr while awake (MAX 8 times/day); day 3-7, 1-2 drops every 4 hr while awake (MAX 4 times/day)
  • Corneal ulcer: (1.5% ophthalmic solution) ages 6 year and older; day 1-3, 1-2 drops every 30 min to 2 hr while awake and 4 hr and 6 hr after retiring; day 4 through treatment end, 1-2 drops every 1 to 4 hr while awake
  • Inhalational anthrax, Post-exposure; Prophylaxis: administration of ORAL or IV levofloxacin to pediatric patients should be based on clinical judgment of risk/benefit for the individual patients; clinical data about the safety of levofloxacin in pediatric patients are lacking
 
Contraindication
hypersensitivity to quinolones.
Precaution
 
Adverse reaction
 
Common
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  • Gastrointestinal: Constipation (3.1% ), Diarrhea (5.4% ), Nausea (6.8% ), Taste sense altered (ophthalmic, 8% to 10% )
  • Neurologic: Headache (ophthalmic, 8% to 10% oral and intravenous, 5.8% ), Insomnia (4.6% )
  • Ophthalmic: Blurred vision, Ophthalmic solution
 
Serious
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  • Cardiovascular: Prolonged QT interval, Torsades de pointes (rare ), Ventricular tachycardia (rare )
  • Dermatologic: Stevens-Johnson syndrome (rare ), Toxic epidermal necrolysis (rare )
  • Endocrine metabolic: Hypoglycemia (0.1% to 0.9% )
  • Hematologic: Aplastic anemia (rare ), Hemolytic anemia (rare ), Pancytopenia (rare ), Thrombocytopenia (rare ), Thrombocytopenic purpura (rare )
  • Hepatic: Hepatic necrosis (rare ), Hepatitis (rare ), Liver failure (0.1% to 0.9% )
  • Immunologic: Anaphylactoid reaction (rare ), Immune hypersensitivity reaction (0.1% to 0.9% )
  • Musculoskeletal: Traumatic or non-traumatic rupture of tendon (rare )
  • Neurologic: Polyneuropathy (rare )
  • Renal: Acute renal failure (0.1% to 0.9% )
  • Respiratory: Extrinsic allergic alveolitis (rare )
  • Other: Serum sickness due to drug (rare )
 
Drug Interaction
 
Pregnancy Category
C
Notes
 
最近更新日期 2015年9月24日