Adult
Reversal of benzodiazepine-induced sedation:
IV, initial 0.2 mg, administered> 15 sec, If the desired response has not been attained after 45 sec-1 min, additional 0.2 mg may be administered> 15 sec at 1 min intervals. Max. cumulative dose: 1 mg. Most patients require 0.6-1 mg. Max. 1 mg/dose or 3 mg/hr
Treatment of benzodiazepine overdose:
IV, initial 0.2 mg, administered> 30 sec. If the desired response has not been obtained after 30 sec- 1min, 0.3 mg may be administered> 30 sec. If necessary, additional doses of 0.5 mg may be administered> 30 sec at 1 min intervals. Max. cumulative dose: 3 mg. Most patients respond to a cumulative dose of 1-3 mg.
Pediatric
Reversal of benzodiazepine-induced sedation:
IV, initial 0.01 mg/kg (Max 0.2 mg) administered> 15 sec. If the desired response has not been attained after 45 sec-1 min, additional 0.01 mg/kg (Max. 0.2 mg) may be administered> 15 sec at 1 min intervals. Max. 5 doses. Max. cumulative dose: 1 mg |
