Adult and pediatric> 40 kg:
Usaual dose: IV infusion, SMX 40-50 mg/kg/d and TMP 8-10 mg/kg/d divided every 6-12 hr.



PCP, treatment: IV, TMP 15-20 mg/kg/d divided every 6 hr for 14-21 days


Pediatric
Usual dose:
Infants3 2 mo,< 40 kg: IV infusion: as adult dose.
Shigellosis: IV, 8-10 mg/kg TMP component /day divided every 6-12 hr for up to 5 days


PCP, treatment: Pediatric 3 2 mo, IV, 15-20 mg/kg TMP component/day divided every 6 hr for 14-21 days

M: Hypersensitivity; photosensitivity; CNS effects; GI disturbances; glossitis or stomatitis
L:Blood dyscrasias; cholestatic hepatitis; pancreatitis; severe skin reactions
R: Hyperkalemia;Hyponatremia;Aseptic meningitis; CNS toxicity; Clostridium difficile colitis; crystalluria or hematuria; thyroid function disturbance; interstitial nephritis or tubular necrosis; methemoglobinemia; rhabdomyolysis (mainly in AIDS patients); thrombophlebitis