Adult
Diabetic peripheral neuropathy - Pain: 60 mg QD.
Fibromyalgia: initial, 30 mg QD for 1 week; increase to
recommended dose of 60 mg once daily based on tolerability
Generalized anxiety disorder: initial, 30 mg QD for 1 week; and
may increase by increments of 30 mg QD to a Max. of 120 mg;
however, doses greater than 60 mg did not provide additional
benefit in clinical trials.
Major depressive disorder: initial (acute), 20 mg BID;
maintenance, 60 mg/day (QD or 30 mg BID).
Pediatric
Safety and efficacy have not been established.

Diaphoresis, constipation, decrease in appetite, diarrhea, nausea, xerostomia; dizziness, insomnia, somnolence; fatigue; abnormal bleeding; hepatotoxicity; depression, worsening, suicidal thoughts; serotonin syndrome, withdrawal signs or symptoms.